May 2013 JPGN Articles
The proportion of infliximab-treated patients developing psoriasis in this cohort was:
A - 5.5%
B - 10.5%
C - 15.5%
D - 20.5%
In the setting of anti-TNF-induced psoriasis, the best management for the patient is as follows:
A - Switch to an alternate anti-TNF therapy
B - Reduce the dose of anti-TNF
C - Continue anti-TNF therapy without further interventions.
D - Continue anti-TNF therapy and consider dermatology referral.
The most common type of psoriasis/psoriasiform skin lesion in this cohort was:
A - Plaque psoriasis (psoriasis vulgaris)
B - Guttate psoriasis
C - Palmoplantar pustular psoriasis
D - Inverse psoriasis
Polymorphisms in the IL-23-receptor gene were explored in this study. Identify the correct statement below.
A - This study firmly establishes that polymorphisms in the IL-23-receptor gene can accurately identify those patients at risk of developing psoriasis/psoriasiform lesions while being treated with anti-TNF-? therapy.
B - Patients developing psoriasis in the setting of anti-TNF-? therapy were more likely to carry polymorphisms in the IL-23-receptor gene than those who did not develop psoriasis; however the study was too small to draw any firm conclusions
C - Patients with IL-23-receptor polymorphisms who developed psoriasis were less likely to respond to topical therapy.
D - None of the above
Indicate which of the following sentences regarding gut-liver axis is correct
A - T cell homing to the liver after priming by gut associated lymphoid tissue(GALT) derived dendritic cells may be a possible basis of extra-intestinal manifestations of chronic inflammatory bowel disease.
B - T cells activated by liver sinusoidal endothelial cells acquire the capacity to home to intestine and the GALT.
C - Gut-liver axis modulates the intestinal microflora, modifies the intestinal barrier function, and determines metabolic effects on near and far organs and systems.
D - All of the above
Indicate which of the following sentences regarding the gut microbiota is correct:
A - Gut microbiota alteration can induce liver insult by influencing the trafficking of molecules from the intestine into the portal circulation
B - Gut microbiota is not influenced by breast feeding and westernized diet
C - Gut microbiota can directly alter metabolic pathways within the liver with subsequent liver insult
D - Gut microbiota can increase the ethanol level in the serum, so causing alcoholic liver disease
Indicate which of the following conditions a have negative effect on gut barrier function/obesity:
A - Reduction in Bacteroidetes and increase in Firmicutes
B - Breast-feeding
C - High fat diet
D - A+C
Which of the following sentences regarding gut microbiota modulation as a reasonable potential treatment of NAFLD is incorrect:
A - Gut microbiota modulation may have influence on near and far organs and systems
B - Gut microbiota modulation may be obtained through pre-, pro-, and sym-biotics
C - Gut microbiota modulation may lead to modification of intestinal barrier function
D - Gut microbiota is insensitive to any kind of modulation