May 2013 JPGN Articles
 
1 - The proportion of infliximab-treated patients developing psoriasis in this cohort was:
A   - 5.5%
B   - 10.5%
C   - 15.5%
D   - 20.5%
2 - In the setting of anti-TNF-induced psoriasis, the best management for the patient is as follows:
A   - Switch to an alternate anti-TNF therapy
B   - Reduce the dose of anti-TNF
C   - Continue anti-TNF therapy without further interventions.
D   - Continue anti-TNF therapy and consider dermatology referral.
3 - The most common type of psoriasis/psoriasiform skin lesion in this cohort was:
A   - Plaque psoriasis (psoriasis vulgaris)
B   - Guttate psoriasis
C   - Palmoplantar pustular psoriasis
D   - Inverse psoriasis
4 - Polymorphisms in the IL-23-receptor gene were explored in this study. Identify the correct statement below.
A   - This study firmly establishes that polymorphisms in the IL-23-receptor gene can accurately identify those patients at risk of developing psoriasis/psoriasiform lesions while being treated with anti-TNF-? therapy.
B   - Patients developing psoriasis in the setting of anti-TNF-? therapy were more likely to carry polymorphisms in the IL-23-receptor gene than those who did not develop psoriasis; however the study was too small to draw any firm conclusions
C   - Patients with IL-23-receptor polymorphisms who developed psoriasis were less likely to respond to topical therapy.
D   - None of the above
5 - Indicate which of the following sentences regarding gut-liver axis is correct
A   - T cell homing to the liver after priming by gut associated lymphoid tissue(GALT) derived dendritic cells may be a possible basis of extra-intestinal manifestations of chronic inflammatory bowel disease.
B   - T cells activated by liver sinusoidal endothelial cells acquire the capacity to home to intestine and the GALT.
C   - Gut-liver axis modulates the intestinal microflora, modifies the intestinal barrier function, and determines metabolic effects on near and far organs and systems.
D   - All of the above
6 - Indicate which of the following sentences regarding the gut microbiota is correct:
A   - Gut microbiota alteration can induce liver insult by influencing the trafficking of molecules from the intestine into the portal circulation
B   - Gut microbiota is not influenced by breast feeding and westernized diet
C   - Gut microbiota can directly alter metabolic pathways within the liver with subsequent liver insult
D   - Gut microbiota can increase the ethanol level in the serum, so causing alcoholic liver disease
7 - Indicate which of the following conditions a have negative effect on gut barrier function/obesity:
A   - Reduction in Bacteroidetes and increase in Firmicutes
B   - Breast-feeding
C   - High fat diet
D   - A+C
8 - Which of the following sentences regarding gut microbiota modulation as a reasonable potential treatment of NAFLD is incorrect:
A   - Gut microbiota modulation may have influence on near and far organs and systems
B   - Gut microbiota modulation may be obtained through pre-, pro-, and sym-biotics
C   - Gut microbiota modulation may lead to modification of intestinal barrier function
D   - Gut microbiota is insensitive to any kind of modulation